Hemoperfusion (Resin Adsorption) & Poisoning

Acute poisoning is common in emergency department of internal medicine. Many clinical research shows that blood purification combined with internal medicine treatment could effectively improve success rate for patients.

HA230 resin hemoperfusion cartridge is of relatively specific recognition and adsorption capacity to various toxins and drugs. In clinic, the product could be used individually by all kinds of blood purification machines or used in association with other blood purification devices for whole-blood or plasma hemoperfusion treatment. The product is especially applicable in clearing fat-soluble macromolecules, circle-sized micromolecules as well as drugs & toxins combined with plasma proteins and clearing organophosphorous pesticide, various drugs, raticide, industrial toxins, biotoxins & other relative toxins.

Adsorption Principle

Adsorbent in HA230 resin hemoperfusion cartridge is the medical macroporous adsorptive resin processed by unique technology, whose adsorption capacity depends on the molecular sieve effect of three–dimensional network structure and the affinity between resin molecular groups and the adsorbed material as well as Van der Waals interaction between molecular groups, and high adsorption capacity is performed to macromolecular toxins, especially the ones with hydrophobic lipophilic groups or aromatic ring structure.

Product Properties

1. Safe application: good biocompatibility, great mechanical strength of adsorbing material and stable adsorbability.

2. High adsorption rate & large adsorption capacity

3. Sterilization with γ ray , no bacterium or pyrogen

Application

1. Acute drug, toxin poisoning, in particular the poisoning with no specific antidote;

2. Dosage exceeds 30% of its self-clearance capacity;

3. The drugs’ or poisons’ blood concentration has reached the lethal dose(LD) or not up to  LD but it is estimated that it will continue to absorb;

4. Drugs or poisons intaking unknown composition and quantity;

5. Poisoning patients is suffering from liver or kidney disease, it is estimated that detoxification or excretion dysfunction exists;

6. Delayed drugs, toxic poisoning.

Below is a toxin list which could be adsorbed by HA230 hemoperfusion cartridge.

Type	Drugs or toxins
barbiturates	barbital, pentobarbital, amobarbital, heptabarbital, secobarbital
Sedative-hypnotics	glutethimide, meprobamate, methaqualone, chloralhydrate, opioids, diphenhydramine, methylprylon, phenytoin, perphenazine, antietam, diazepam, librium, chlorpromazine, chlorprothixene, phenergan
Alcohols	methanol, ethanol, isopropanol, ethylene glycol
Anodyne	aspirin, salicylate, cresotic acid, henacetin
Antibiotics	penicillin, streptomycin, tetracycline, kanamycin, gentamicin,quinine, ampicillin, neomycin, vancomycin, sulfonamides, chloromycetin, polymyxin, isoniazid
Other drugs	atropine, phenols, chloroquine, thyroxine, morphine-likepeptide, thiocyanate, CIT, carbontetrachloride, ergotamine, ammoniumphosphate, trichloroethylene, 5-fluorouracil, amethopterin, camphor
In vivo toxins	ammonia, carbamide, bilirubin, lactic acid, cystine, endotoxin
Poison	dimethoate, parathion, chlorinated pesticide
Metal	arsenic, cuprum, calcium, plumbum, hydrargyrum and so on
Phytotoxins	akebia stem, mushroom posioning, aconite
Biotoxins	maesa perlaria, balloonfish, snake venom, bee venom, scorpion venom
Antidepressant drugs	imipramine, chlorimipramine
Cardiovascular drugs	digitoxin, digoxin
Halide	bromide, chloride, iodide, fluoride

Clearance capacity of HA230 resin hemoperfusion carfridge for some common toxins